Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.
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ABSTRACT:
SUBMITTER: Fukunaka A
PROVIDER: S-EPMC5855698 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.
Fukunaka Ayako A Fujitani Yoshio Y
International journal of molecular sciences 20180206 2
Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough discovery that the common polymorphism in zinc transporter <i>SLC30A8</i>/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes. Our group and others showed that altered ZnT8 function may be involved in the pathogenesis of type 2 diabetes, indicating that the precise control of zinc homeo ...[more]
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