Ontology highlight
ABSTRACT:
SUBMITTER: Didychuk AL
PROVIDER: S-EPMC5855946 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20180124 4
Removal of introns from precursor messenger RNA (pre-mRNA) and some noncoding transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of RNA splicing is carried out by the spliceosome, a multi-megaDalton macromolecular machine whose core components are conserved from yeast to humans. In addition to many proteins, the spliceosome contains five uridine-rich small nuclear RNAs (snRNAs) that undergo an elaborate series of conformational changes to correctly recog ...[more]