Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC5856174 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wang Sheng S Wacker Daniel D Levit Anat A Che Tao T Betz Robin M RM McCorvy John D JD Venkatakrishnan A J AJ Huang Xi-Ping XP Dror Ron O RO Shoichet Brian K BK Roth Bryan L BL
Science (New York, N.Y.) 20171001 6361
Dopamine receptors are implicated in the pathogenesis and treatment of nearly every neuropsychiatric disorder. Although thousands of drugs interact with these receptors, our molecular understanding of dopaminergic drug selectivity and design remains clouded. To illuminate dopamine receptor structure, function, and ligand recognition, we determined crystal structures of the D<sub>4</sub> dopamine receptor in its inactive state bound to the antipsychotic drug nemonapride, with resolutions up to 1. ...[more]