Ontology highlight
ABSTRACT:
SUBMITTER: Panduro M
PROVIDER: S-EPMC5856564 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180223 11
Skeletal muscle regeneration is a highly orchestrated process that depends on multiple immune-system cell types, notably macrophages (MFs) and Foxp3<sup>+</sup>CD4<sup>+</sup> regulatory T (T<sub>reg</sub>) cells. This study addressed how T<sub>reg</sub> cells rein in MFs during regeneration of murine muscle after acute injury with cardiotoxin. We first delineated and characterized two subsets of MFs according to their expression of major histocompatibility complex class II (MHCII) molecules, i. ...[more]