Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols.

ABSTRACT: Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5856650 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature