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Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols.

ABSTRACT: Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.

SUBMITTER: Zhang H

PROVIDER: S-EPMC5856650 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols.

Zhang Hong H Ruiz-Castillo Paula P Buchwald Stephen L SL

Organic letters 20180223 6

Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions. ...[more]

PMID: 29474078

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