Ontology highlight
ABSTRACT:
SUBMITTER: Pellegrino S
PROVIDER: S-EPMC5857200 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Pellegrino Stefania S Michelena Jone J Teloni Federico F Imhof Ralph R Altmeyer Matthias M
Cell reports 20170501 9
The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection. How this function is regulated locally and across the cell cycle to channel repair reactions toward non-homologous end joining (NHEJ) in G1 and promote homology-directed repair (HDR) in S/G2 is insufficiently understood. Here, we show that the ability of 53BP1 to accumulate around DSBs declines as cells progress throug ...[more]