Ontology highlight
ABSTRACT:
SUBMITTER: Spiller KJ
PROVIDER: S-EPMC5857237 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Spiller Krista J KJ Restrepo Clark R CR Khan Tahiyana T Dominique Myrna A MA Fang Terry C TC Canter Rebecca G RG Roberts Christopher J CJ Miller Kelly R KR Ransohoff Richard M RM Trojanowski John Q JQ Lee Virginia M-Y VM
Nature neuroscience 20180220 3
Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. However, only subtle microglial changes were detected during disease in the spinal cord, despite progressive motor neuron loss; microglia still reacted to inflammatory triggers in these m ...[more]