Hypolipidemic Effect of Psidium guajava Leaf Extract Against Hepatotoxicity in Rats.

ABSTRACT:

Background

Plant-based natural extracts cure several diseases in human. However, the extract of Psidium guajava leaf is not yet evaluated on changes of lipid profile in hepatic disease affected rats.

Objective

The present study was aimed to evaluate the mitigation effect of the ethanolic extract of P. guajava leaf and its isolated quercetin fraction on hepatotoxic rats.

Materials and methods

Carbon tetrachloride (CCl₄) was injected to rats for hepatic disease induction and silymarin drug was used as positive control to compare plant ethanolic extract. The lipid profiles were assessed in both plasma and liver tissue of diseased and control rats.

Results

Levels of total cholesterol, triglycerides, free fatty acids, phospholipids, and low-

SUBMITTER: Vijayakumar K 

PROVIDER: S-EPMC5858240 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature