Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages.

ABSTRACT: Lung alveolar macrophages (AMs) are in the first line of immune defense against respiratory pathogens and play key roles in the pathogenesis of Mycobacterium tuberculosis (Mtb) in humans. Nevertheless, AMs are available only in limited amounts for in vitro studies, which hamper the detailed molecular understanding of host-Mtb interactions in these macrophages. The recent establishment of the self-renewing and primary Max Planck Institute (MPI) cells, functionally very close to lung AMs, opens unique opportunities for in vitro studies of host-pathogen interactions in respiratory diseases. Here, we investigated the suitability of MPI cells as a host cell system for Mtb infection. Bacterial, cellular, and innate immune features of MPI cells infected w

SUBMITTER: Woo M 

PROVIDER: S-EPMC5858468 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature