Unknown

Dataset Information

0

GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study.


ABSTRACT: Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between functional SNPs and risk of RP. Methods: We recruited a total of 149 lung cancer patients who had received intensity modulated radiation therapy (IMRT). GSTP1 and XRCC1 were genotyped using the SurPlexTM-xTAG method in all patients. RP events were prospectively scored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Kaplan-Meier analysis was used to determine the cumulative probability of RP of grade ? 2. Cox proportional hazard regression was performed to identify clinical variables and SNPs associated with risk of RP grade ? 2, using univariate and multivariate analysis, respectively. Results: With a median follow-up of 9 months, the incidence of RP of grade ? 2 was 38.3%. A predicting role in RP was observed for the GSTP1 SNP (adjusted hazard ratio 3.543; 95% CI 1.770-7.092; adjusted P< 0.001 for the Ile/Val and Val/Val genotypes versus Ile/Ile genotype). Whereas, we found that patients with XRCC1 399Arg/Gln and Gln/Gln genotypes had a lower risk of RP compares with those carrying Arg/Arg genotype (adjusted HR 0.653; 95% CI 0.342-1.245), but with no statistical significance observed (adjusted P = 0.195). Conclusions: Our results suggested a novel association between GSTP1 SNP 105Ile/Val and risk of RP development, which suggests the potential use of this genetic polymorphism as a predictor of RP. In addition, genetic polymorphisms of XRCC1 399Arg/Gln may also be associated with RP.

SUBMITTER: Du L 

PROVIDER: S-EPMC5858494 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study.

Du Lehui L   Yu Wei W   Huang Xiang X   Zhao Nana N   Liu Fang F   Tong Fang F   Zhang Sujing S   Niu Baolong B   Liu Xiaoliang X   Xu Shouping S   Huang Yurong Y   Dai Xiangkun X   Xie Chuanbin C   Chen Gaoxiang G   Cong Xiaohu X   Qu Baolin B  

Journal of Cancer 20180201 4


<b>Background:</b> Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between functional SNPs and risk of RP. <b>Methods:</b> We recruited a total of 149 lung cancer patients who had received  ...[more]

Similar Datasets

| S-EPMC3747220 | biostudies-literature
| S-EPMC4913997 | biostudies-literature
| S-EPMC8297824 | biostudies-literature
| S-EPMC3492338 | biostudies-literature
| S-EPMC4013574 | biostudies-literature
| S-EPMC5735339 | biostudies-literature
| S-EPMC8755838 | biostudies-literature
| S-EPMC5134397 | biostudies-literature
| S-EPMC7143748 | biostudies-literature
| S-EPMC5406240 | biostudies-literature