Genetic Evidence for Early Peritoneal Spreading in Pelvic High-Grade Serous Cancer.

ABSTRACT:

Background

Most pelvic high-grade serous (HGS) carcinomas have been proposed to arise from tubal primaries that progress rapidly to advanced disease. However, the temporal sequence of ovarian and peritoneal metastases is not well characterized.

Methods

To establish the sequence of metastases, phylogenetic relationships among the ovarian and peritoneal carcinomas were determined from single-nucleotide variations (SNVs) in nine tumor regions from each patient with pelvic HGS carcinomas. Somatic SNVs from each tumor sample were used to reconstruct phylogenies of samples from each patient. Variant allele frequencies were used to reconstruct subclone phylogenies in each tumor sample.

Results

We show that pelvic HGS carcinomas are highly heterogeneous, only sharing less tha

SUBMITTER: Chien J 

PROVIDER: S-EPMC5858520 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature