A variant in the SCN10A enhancer may affect human mechanical pain sensitivity.
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ABSTRACT:
SUBMITTER: Duan G
PROVIDER: S-EPMC5858611 | biostudies-literature | 2018 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
A variant in the SCN10A enhancer may affect human mechanical pain sensitivity.
Duan Guangyou G Sun Jiaoli J Li Ningbo N Zheng Hua H Guo Shanna S Zhang Yuhao Y Wang Qingli Q Ying Ying Y Zhang Mi M Huang Penghao P Zhang Xianwei X
Molecular pain 20180101
Expression of Nav1.8, encoded by SCN10A, can affect pain transmission and thus mediate the human pain phenotype. In the current study, we assessed whether the variant rs6801957, located in the SCN10A enhancer region, may have the potential to affect human pain. Through dual-luciferase reporter assays in 293T cells, we found that the SCN10A enhancer A (Enh-A) increased the activity of the SCN10A promoter ( P < 0.05). Additionally, in a cohort of 309 healthy women, mutant rs6801957 A/A was found t ...[more]
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