Ontology highlight
ABSTRACT:
SUBMITTER: Ortiz-Romero P
PROVIDER: S-EPMC5858783 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ortiz-Romero Paula P Borralleras Cristina C Bosch-Morató Mònica M Guivernau Biuse B Albericio Guillermo G Muñoz Francisco J FJ Pérez-Jurado Luis A LA Campuzano Victoria V
PloS one 20180319 3
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. The complete deletion (CD) mouse model mimics the most common deletion found in WBS patients and recapitulates most neurologic features of the disorder along with some cardiovascular manifestations leading to significant cardiac hypertrophy with increased cardiomyocytes' size. Epigallocatechin-3-gallate (EGCG), the most abundant catechin found in green tea, ...[more]