In vivo ¹⁸F-AV-1451 tau PET signal in MAPT mutation carriers varies by expected tau isoforms.

ABSTRACT:

Objective

To evaluate ¹⁸F-AV-1451 tau PET binding among microtubule-associated protein tau (MAPT) mutation carriers.

Methods

Using a case-control study, we quantitatively and qualitatively compared tau PET scans in 10 symptomatic and 3 asymptomatic MAPT mutation carriers (n = 13, age range 42-67 years) with clinically normal (CN) participants (n = 241, age range 42-67 years) and an Alzheimer disease (AD) dementia cohort (n = 30, age range 52-67 years). Eight participants had MAPT mutations that involved exon 10 (N279K n = 5, S305N n = 2, P301L n = 1) and tend to form 4R tau pathology, and 5 had mutations outside exon 10 (V337M n = 2, R406W n = 3) and tend to form mixed 3R/4R tau pathology.

Results

Tau PET signal was qualitatively and quantitat

SUBMITTER: Jones DT 

PROVIDER: S-EPMC5858948 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature