Relations of mitochondrial genetic variants to measures of vascular function.
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ABSTRACT:
SUBMITTER: Fetterman JL
PROVIDER: S-EPMC5858959 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Relations of mitochondrial genetic variants to measures of vascular function.
Fetterman Jessica L JL Liu Chunyu C Mitchell Gary F GF Vasan Ramachandran S RS Benjamin Emelia J EJ Vita Joseph A JA Hamburg Naomi M NM Levy Daniel D
Mitochondrion 20171007
Mitochondrial genetic variation with resultant alterations in oxidative phosphorylation may influence vascular function and contribute to cardiovascular disease susceptibility. We assessed relations of peptide-encoding variants in the mitochondrial genome with measures of vascular function in Framingham Heart Study participants. Of 258 variants assessed, 40 were predicted to have functional consequences by bioinformatics programs. A maternal pattern of heritability was estimated to contribute to ...[more]
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