Ontology highlight
ABSTRACT:
SUBMITTER: Rocha AG
PROVIDER: S-EPMC5858965 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Rocha Agostinho G AG Knight Simon A B SAB Pandey Alok A Yoon Heeyong H Pain Jayashree J Pain Debkumar D Dancis Andrew A
Mitochondrion 20170921
The cysteine desulfurase Nfs1/Isd11 uses the amino acid cysteine as the substrate and its activity is absolutely required for contributing persulfide sulfur to the essential process of iron-sulfur (Fe-S) cluster assembly in mitochondria. Here we describe a novel regulatory process involving phosphorylation of Nfs1 in mitochondria. Phosphorylation enhanced cysteine desulfurase activity, while dephosphorylation decreased its activity. Nfs1 phosphopeptides were identified, and the corresponding pho ...[more]