Changes in brain connectivity during a sham-controlled, transcranial magnetic stimulation trial for depression.

ABSTRACT:

Background

The subgenual anterior cingulate cortex (sgACC) has been implicated in major depressive disorder (MDD), and this study evaluated sgACC connectivity before and after repetitive transcranial magnetic stimulation (rTMS) treatment.

Methods

Thirty-two MDD patients entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex (dlFPC). Subjects underwent resting state functional magnetic resonance imaging before and after 20 sessions of high frequency rTMS. Seed voxels identified the affective network (AN; sgACC, amygdala), default mode network (DMN; posterior cingulate cortex [PCC]), and fronto-parietal network (FPN; dlPFC stimulation site).

Results

There was no significant effect of active rTMS over sham on the pr

SUBMITTER: Taylor SF 

PROVIDER: S-EPMC5858982 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature