Ontology highlight
ABSTRACT:
SUBMITTER: Hamamoto H
PROVIDER: S-EPMC5859037 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hamamoto Hiroki H Maemura Kentaro K Matsuo Kentaro K Taniguchi Kohei K Tanaka Yoshihisa Y Futaki Sugiko S Takeshita Atsushi A Asai Akira A Hayashi Michihiro M Hirose Yoshinobu Y Kondo Yoichi Y Uchiyama Kazuhisa K
Scientific reports 20180319 1
Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. We previously showed that expression of Delta-like 3 (DLL3), a member of the family of Delta/Serrate/Lag2 ligands for the Notch receptor, is silenced by aberrant DNA methylation and that overexpression of DLL3 in an HCC cell line induces cellular apoptosis. However, how DLL3 expression is regulated during hepatocarcinogenesis is still unclear. Here, we show that silencing of DLL3 during hepatocarcinogenesis is closel ...[more]