Ontology highlight
ABSTRACT:
SUBMITTER: Sengupta S
PROVIDER: S-EPMC5859297 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sengupta Soham S Nechushtai Rachel R Jennings Patricia A PA Onuchic Jose' N JN Padilla Pamela A PA Azad Rajeev K RK Mittler Ron R
Scientific reports 20180319 1
The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in diabetes, obesity, cancer, aging, cardiovascular disease and neurodegeneration. Despite the important biological role of the CDGSH domain, its origin, evolution and diversification, are largely unknown. Here, we report that: (1) the CDGSH domain appeared early in evolution, perhaps linked to the he ...[more]