Serum uric acid and renal function in patients with type 1 diabetes: a nationwide study in Brazil.

ABSTRACT:

Background

Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the association between levels of serum uric acid and renal function assessed by glomerular filtration rate (GFR) and albuminuria in patients with type 1 diabetes.

Methods

This is a multicenter, cross-sectional, observational study with 1686 patients, conducted between August 2011 and August 2014 in 14 public clinics from ten Brazilian cities. Renal function was estimated by CKD-EPI (adults) and by Schwartz (adolescents).

Results

We analyzed 1686 patients, aged 30.1 ± 12.0, with 15.4 ± 9.3 years of duration of diabetes; 55.8% were female and 54.0% were Caucas

SUBMITTER: Pizarro MH 

PROVIDER: S-EPMC5859721 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature