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Serum uric acid and renal function in patients with type 1 diabetes: a nationwide study in Brazil.
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ABSTRACT: Background
Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the association between levels of serum uric acid and renal function assessed by glomerular filtration rate (GFR) and albuminuria in patients with type 1 diabetes.Methods
This is a multicenter, cross-sectional, observational study with 1686 patients, conducted between August 2011 and August 2014 in 14 public clinics from ten Brazilian cities. Renal function was estimated by CKD-EPI (adults) and by Schwartz (adolescents).Results
We analyzed 1686 patients, aged 30.1?±?12.0, with 15.4?±?9.3 years of duration of diabetes; 55.8% were female and 54.0% were Caucasians. Serum uric acid was related to renal function, with a mean of 4.8?±?1.4 (in the normal renal function group) vs 5.2?±?2.0 (GFR???60 ml/min and albuminuria) vs 6.5?±?2.6 mg/dl (GFR?ConclusionsPatients with higher levels of serum uric acid have worse renal function, independently of HbA1c or duration of diabetes, which persisted even in patients with normal renal function. Further prospective studies are necessary to establish if patients with higher serum uric acid may have an elevated risk for developing chronic kidney disease.
SUBMITTER: Pizarro MH
PROVIDER: S-EPMC5859721 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Serum uric acid and renal function in patients with type 1 diabetes: a nationwide study in Brazil.
Diabetology & metabolic syndrome 20180320
<h4>Background</h4>Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the association between levels of serum uric acid and renal function assessed by glomerular filtration rate (GFR) and albuminuria in patients with type 1 diabetes.<h4>Methods</h4>This is a multicenter, cross-sectional, observational study with 1686 patients, conducted between Au ...[more]