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Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population.


ABSTRACT: Recent GWAS-associated studies reported that single nucleotide polymorphisms (SNPs) in ABCB1, TGF?1, XRCC1 genes were associated with hepatitis A virus (HAV) infection, and variants of APOA4 and APOE genes were associated with and hepatitis E virus (HEV) infection in US population. However, the associations of these loci with HAV or HEV infection in Chinese Han population remain unclear.A total of 3082 Chinese Han persons were included in this study. Anti-HAV IgG and anti-HEV IgG were detected by enzyme-linked immunosorbent assay (ELISA). Genotypes in ABCB1, TGF?1, XRCC1, APOA4 and APOE SNPs were determined by TaqMan MGB technology.In Chinese Han population, rs1045642 C to T variation in ABCB1 was significantly associated with the decreased risk of HAV infection (P?

SUBMITTER: Gu M 

PROVIDER: S-EPMC5859746 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population.

Gu Maolin M   Qiu Jing J   Guo Daoxia D   Xu Yunfang Y   Liu Xingxiang X   Shen Chong C   Dong Chen C  

Virology journal 20180320 1


<h4>Background</h4>Recent GWAS-associated studies reported that single nucleotide polymorphisms (SNPs) in ABCB1, TGFβ1, XRCC1 genes were associated with hepatitis A virus (HAV) infection, and variants of APOA4 and APOE genes were associated with and hepatitis E virus (HEV) infection in US population. However, the associations of these loci with HAV or HEV infection in Chinese Han population remain unclear.<h4>Methods</h4>A total of 3082 Chinese Han persons were included in this study. Anti-HAV I  ...[more]

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