Ontology highlight
ABSTRACT:
SUBMITTER: Grinberg-Bleyer Y
PROVIDER: S-EPMC5860980 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Grinberg-Bleyer Yenkel Y Caron Rachel R Seeley John J JJ De Silva Nilushi S NS Schindler Christian W CW Hayden Matthew S MS Klein Ulf U Ghosh Sankar S
Journal of immunology (Baltimore, Md. : 1950) 20180219 7
CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) are essential regulators of immune responses. Perturbation of Treg homeostasis or function can lead to uncontrolled inflammation and autoimmunity. Therefore, understanding the molecular mechanisms involved in Treg biology remains an active area of investigation. It has been shown previously that the NF-κB family of transcription factors, in particular, the canonical pathway subunits, c-Rel and p65, are crucial for the development, maint ...[more]