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Bone-related Circulating MicroRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry.

ABSTRACT: The assessment of bone quality and the prediction of fracture risk in idiopathic osteoporosis (IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) are promising new biomarkers for bone diseases, but the current understanding of the biological information contained in the variability of miRNAs is limited. Here, we investigated the association between serum-levels of 19 miRNA biomarkers of idiopathic osteoporosis to bone microstructure and bone histomorphometry based upon bone biopsies and µCT (9.3 ?m) scans from 36 patients. Four miRNAs were found to be correlated to bone microarchitecture and seven miRNAs to dynamic histomorphometry (p?

SUBMITTER: Feichtinger X 

PROVIDER: S-EPMC5861059 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Bone-related Circulating MicroRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry.

Feichtinger Xaver X   Muschitz Christian C   Heimel Patrick P   Baierl Andreas A   Fahrleitner-Pammer Astrid A   Redl Heinz H   Resch Heinrich H   Geiger Elisabeth E   Skalicky Susanna S   Dormann Rainer R   Plachel Fabian F   Pietschmann Peter P   Grillari Johannes J   Hackl Matthias M   Kocijan Roland R  

Scientific reports 20180320 1

The assessment of bone quality and the prediction of fracture risk in idiopathic osteoporosis (IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) are promising new biomarkers for bone diseases, but the current understanding of the biological information contained in the variability of miRNAs is limited. Here, we investigated the association between serum-levels of 19 miRNA biomarkers of idiopathic osteoporosi  ...[more]

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