Redefining the ancestral origins of the interleukin-1 superfamily.
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ABSTRACT:
SUBMITTER: Rivers-Auty J
PROVIDER: S-EPMC5861070 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Redefining the ancestral origins of the interleukin-1 superfamily.
Rivers-Auty Jack J Daniels Michael J D MJD Colliver Isaac I Robertson David L DL Brough David D
Nature communications 20180320 1
The interleukin-1 (IL-1) receptor and ligand families are components of the immune system. Knowledge of their evolutionary history is essential to understand their function. Using chromosomal anatomy and sequence similarity, we show that IL-1 receptor family members are related and nine members are likely formed from duplication and modification of a proto-IL-1R1 receptor. The IL-1 ligands have a different evolutionary history. The first proto-IL-1β gene coincided with proto-IL-1R1 and duplicati ...[more]
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