Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5861525 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Chemical science 20150519 8
The first Pd-catalyzed regioselective γ-carbonylation of oxalyl amide protected aliphatic amines with carbon monoxide leading to synthesis of pyrrolidones has been developed. Both γ-methyl and cyclopropyl methylene C-H bonds are well activated to obtain the corresponding pyrrolidones in moderate to excellent yields. The role of 3-(trifluoromethyl)benzoic acid as an additive is critical as it helps in stabilizing the palladium intermediate formed during the catalytic cycle. The reaction scope is ...[more]