Ontology highlight
ABSTRACT:
SUBMITTER: Tompkins BA
PROVIDER: S-EPMC5861900 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Tompkins Bryon A BA DiFede Darcy L DL Khan Aisha A Landin Ana Marie AM Schulman Ivonne Hernandez IH Pujol Marietsy V MV Heldman Alan W AW Miki Roberto R Goldschmidt-Clermont Pascal J PJ Goldstein Bradley J BJ Mushtaq Muzammil M Levis-Dusseau Silvina S Byrnes John J JJ Lowery Maureen M Natsumeda Makoto M Delgado Cindy C Saltzman Russell R Vidro-Casiano Mayra M Da Fonseca Moisaniel M Golpanian Samuel S Premer Courtney C Medina Audrey A Valasaki Krystalenia K Florea Victoria V Anderson Erica E El-Khorazaty Jill J Mendizabal Adam A Green Geoff G Oliva Anthony A AA Hare Joshua M JM
The journals of gerontology. Series A, Biological sciences and medical sciences 20171001 11
<h4>Background</h4>Aging frailty, characterized by decreased physical and immunological functioning, is associated with stem cell depletion. Human allogeneic mesenchymal stem cells (allo-hMSCs) exert immunomodulatory effects and promote tissue repair.<h4>Methods</h4>This is a randomized, double-blinded, dose-finding study of intravenous allo-hMSCs (100 or 200-million [M]) vs placebo delivered to patients (n = 30, mean age 75.5 ± 7.3) with frailty. The primary endpoint was incidence of treatment- ...[more]