Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.

ABSTRACT:

Introduction

Invasive pneumococcal disease (IPD), caused by Streptococcus pneumoniae, is a leading cause of pneumonia, meningitis and septicaemia worldwide, with increased morbidity and mortality in HIV-infected children.

Objectives

We aimed to compare peripheral blood expression profiles between HIV-infected and uninfected children with pneumococcal meningitis and controls, and between survivors and non-survivors, in order to provide insight into the host inflammatory response leading to poorer outcomes.

Design and setting

Prospective case-control observational study in a tertiary hospital in Malawi.

Participants

Children aged 2 months to 16 years with pneumococcal meningitis or pneumonia.

Methods

We used the human genome HGU133A Affymetrix array

SUBMITTER: Kulohoma BW 

PROVIDER: S-EPMC5862186 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature