Unknown

Dataset Information

0

Non-alcoholic fatty liver disease in 2016.


ABSTRACT: INTRODUCTION:Non-alcoholic fatty liver disease is the commonest cause of liver disease worldwide, and is rapidly becoming the leading indication for liver transplantation. SOURCES OF DATA:Original articles, reviews and meta-analyses, guidelines. AREAS OF AGREEMENT:NAFLD strongly correlates with obesity and insulin resistance; currently, the best management strategy is weight loss and treatment of the metabolic syndrome. AREAS OF CONTROVERSY:Recent data suggest that the presence of fibrosis and not non-alcoholic steatohepatitis (NASH) is the predictor of clinical outcome. GROWING POINTS:Many phase 2 and 3 trials are underway. Drugs hoped to be effective are obeticholic acid, elafibranor, glucagon-like peptide-1 analogues and CCR2/5 inhibitors. AREAS TIMELY FOR DEVELOPING RESEARCH:Improved understanding of the pathophysiology of NAFLD should help us identify which patients progress to significant liver disease and to develop therapies to target this population.

SUBMITTER: Townsend SA 

PROVIDER: S-EPMC5862239 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Non-alcoholic fatty liver disease in 2016.

Townsend S A SA   Newsome Philip N PN  

British medical bulletin 20160819 1


<h4>Introduction</h4>Non-alcoholic fatty liver disease is the commonest cause of liver disease worldwide, and is rapidly becoming the leading indication for liver transplantation.<h4>Sources of data</h4>Original articles, reviews and meta-analyses, guidelines.<h4>Areas of agreement</h4>NAFLD strongly correlates with obesity and insulin resistance; currently, the best management strategy is weight loss and treatment of the metabolic syndrome.<h4>Areas of controversy</h4>Recent data suggest that t  ...[more]

Similar Datasets

| S-EPMC6334080 | biostudies-literature
| S-EPMC6758911 | biostudies-literature
| S-EPMC10224312 | biostudies-literature
| S-EPMC3040121 | biostudies-literature
| S-EPMC4922334 | biostudies-literature
| S-EPMC4958712 | biostudies-literature
2013-08-30 | E-GEOD-49542 | biostudies-arrayexpress
| S-EPMC4943559 | biostudies-literature
| S-EPMC8895200 | biostudies-literature
| S-EPMC4462685 | biostudies-other