Dataset Information

An Examination of the Application of the Kidney Donor Risk Index in British Columbia.

ABSTRACT:

Background

The Kidney Donor Risk Index (KDRI) is a continuous measure of deceased donor kidney transplant failure risk that was derived in US patients based on 10 donor characteristics. In the United States, the KDRI is utilized to guide organ allocation and to inform clinical decisions regarding organ acceptance.

Objective

To examine the application of the US-derived KDRI in a large Canadian province.

Patients

All deceased donor kidney-only transplant recipients in British Columbia (BC) between 2005 and 2014.

Methods

We examined the predictive performance of KDRI in BC transplant recipients and compared the overall performance of KDRI with donor age alone in predicting transplant failure (from all causes including death).

Results

Donors in BC (N = 785) were older but included no black donors and few Hepatitis C virus (HCV)-positive donors compared with the original derivation cohort of the KDRI in the United States. The KDRI was moderately predictive of transplant failure (c statistic, 0.63) and had similar predictive performance to donor age alone (c statistic, 0.64).

Conclusion

Our findings suggest that the US-derived KDRI does not improve the prediction of kidney transplant failure compared with donor age alone in a Canadian cohort and highlight the need to determine the applicability of KDRI in different regions.

SUBMITTER: Rose C

PROVIDER: S-EPMC5862363 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

An Examination of the Application of the Kidney Donor Risk Index in British Columbia.

Rose Caren C Sun Yvonne Y Ferre Ed E Gill John J Landsberg David D Gill Jagbir J

Canadian journal of kidney health and disease 20180319

<h4>Background</h4>The Kidney Donor Risk Index (KDRI) is a continuous measure of deceased donor kidney transplant failure risk that was derived in US patients based on 10 donor characteristics. In the United States, the KDRI is utilized to guide organ allocation and to inform clinical decisions regarding organ acceptance.<h4>Objective</h4>To examine the application of the US-derived KDRI in a large Canadian province.<h4>Patients</h4>All deceased donor kidney-only transplant recipients in British ...[more]

PMID: 29581885

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Project description:BackgroundWest Nile virus (WNv) has recently emerged as a health threat to the North American population. After the initial disease outbreak in New York City in 1999, WNv has spread widely and quickly across North America to every contiguous American state and Canadian province, with the exceptions of British Columbia (BC), Prince Edward Island and Newfoundland. In this study we develop models of mosquito population dynamics for Culex tarsalis and C. pipiens, and create a spatial risk assessment of WNv prior to its arrival in BC by creating a raster-based mosquito abundance model using basic geographic and temperature data. Among the parameters included in the model are spatial factors determined from the locations of BC Centre for Disease Control mosquito traps (e.g., distance of the trap from the closest wetland or lake), while other parameters were obtained from the literature. Factors not considered in the current assessment but which could influence the results are also discussed.ResultsSince the model performs much better for C. tarsalis than for C. pipiens, the risk assessment is carried out using the output of C. tarsalis model. The result of the spatially-explicit mosquito abundance model indicates that the Okanagan Valley, the Thompson Region, Greater Vancouver, the Fraser Valley and southeastern Vancouver Island have the highest potential abundance of the mosquitoes. After including human population data, Greater Vancouver, due to its high population density, increases in significance relative to the other areas.ConclusionCreating a raster-based mosquito abundance map enabled us to quantitatively evaluate WNv risk throughout BC and to identify the areas of greatest potential risk, prior to WNv introduction. In producing the map important gaps in our knowledge related to mosquito ecology in BC were identified, as well, it became evident that increased efforts in bird and mosquito surveillance are required if more accurate models and maps are to be produced. Access to real time climatic data is the key for developing a real time early warning system for forecasting vector borne disease outbreaks, while including social factors is important when producing a detailed assessment in urban areas.

Dataset Information

An Examination of the Application of the Kidney Donor Risk Index in British Columbia.

Background

Objective

Patients

Methods

Results

Conclusion

Publications

An Examination of the Application of the Kidney Donor Risk Index in British Columbia.

Similar Datasets

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