Ontology highlight
ABSTRACT:
SUBMITTER: Hammer M
PROVIDER: S-EPMC5862414 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Cell reports 20151008 3
Loss-of-function mutations in the synaptic adhesion protein Neuroligin-4 are among the most common genetic abnormalities associated with autism spectrum disorders, but little is known about the function of Neuroligin-4 and the consequences of its loss. We assessed synaptic and network characteristics in Neuroligin-4 knockout mice, focusing on the hippocampus as a model brain region with a critical role in cognition and memory, and found that Neuroligin-4 deletion causes subtle defects of the pro ...[more]