Ontology highlight
ABSTRACT:
SUBMITTER: Torres J
PROVIDER: S-EPMC5862528 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Torres Joana J Monti Remo R Moore Ariane L AL Seimiya Makiko M Jiang Yanrui Y Beerenwinkel Niko N Beisel Christian C Beira Jorge V JV Paro Renato R
eLife 20180321
Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulators are among the most frequently mutated genes in cancer, it is not well understood how an abnormal epigenetic condition contributes to tumor onset. In this work, we investigated the gene signature of tumors caused by disruption of the <i>Drosophila</i> epigenetic regulator, <i>polyhomeotic (ph).</i ...[more]