Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC5863528 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Developmental dynamics : an official publication of the American Association of Anatomists 20100801 8
Studies of Lmx1b have shown that it is required for anterior segment formation during embryonic development and that reduction of Lmx1b may contribute to elevated intraocular pressure in the adult. However, whether Lmx1b is required for formation of anterior segment tissues that are associated with regulation of intraocular pressure has not been addressed due to the perinatal lethality of Lmx1b null allele. Here we use conditional deletion strategies to circumvent perinatal lethality. Our result ...[more]