Ontology highlight
ABSTRACT:
SUBMITTER: Nazer E
PROVIDER: S-EPMC5864089 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nazer Ezequiel E Dale Ryan K RK Chinen Madoka M Radmanesh Behram B Lei Elissa P EP
PLoS genetics 20180312 3
Drosophila Argonaute2 (AGO2) has been shown to regulate expression of certain loci in an RNA interference (RNAi)-independent manner, but its genome-wide function on chromatin remains unknown. Here, we identified the nuclear scaffolding protein LaminB as a novel interactor of AGO2. When either AGO2 or LaminB are depleted in Kc cells, similar transcription changes are observed genome-wide. In particular, changes in expression occur mainly in active or potentially active chromatin, both inside and ...[more]