Ontology highlight
ABSTRACT:
SUBMITTER: Herrero D
PROVIDER: S-EPMC5864208 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Herrero Diego D Tomé María M Cañón Susana S Cruz Francisco M FM Carmona Rosa María RM Fuster Encarna E Roche Enrique E Bernad Antonio A
Cell death and differentiation 20180111 4
Accumulation of reactive oxygen species (ROS) is associated with several cardiovascular pathologies and with cell cycle exit by neonanatal cardiomyocytes, a key limiting factor in the regenerative capacity of the adult mammalian heart. The polycomb complex component BMI1 is linked to adult progenitors and is an important partner in DNA repair and redox regulation. We found that high BMI1 expression is associated with an adult Sca1<sup>+</sup> cardiac progenitor sub-population with low ROS levels ...[more]