Peptide ion channel toxins from the bootlace worm, the longest animal on Earth.
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ABSTRACT:
SUBMITTER: Jacobsson E
PROVIDER: S-EPMC5864730 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Peptide ion channel toxins from the bootlace worm, the longest animal on Earth.
Jacobsson Erik E Andersson Håkan S HS Strand Malin M Peigneur Steve S Eriksson Camilla C Lodén Henrik H Shariatgorji Mohammadreza M Andrén Per E PE Lebbe Eline K M EKM Rosengren K Johan KJ Tytgat Jan J Göransson Ulf U
Scientific reports 20180322 1
Polypeptides from animal venoms have found important uses as drugs, pharmacological tools, and within biotechnological and agricultural applications. We here report a novel family of cystine knot peptides from nemertean worms, with potent activity on voltage-gated sodium channels. These toxins, named the α-nemertides, were discovered in the epidermal mucus of Lineus longissimus, the 'bootlace worm' known as the longest animal on earth. The most abundant peptide, the 31-residue long α-1, was isol ...[more]
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