Ontology highlight
ABSTRACT:
SUBMITTER: Ye F
PROVIDER: S-EPMC5864733 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature communications 20180322 1
The T3SS chaperone CesT is recently shown to interact with the post-transcriptional regulator CsrA to modulate post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. The molecular basis of the CesT/CsrA binding, however, remains elusive. Here, we show that CesT and CsrA both created two ligand binding sites in their homodimers, forming irregular multimeric complexes in solution. Through construction of a recombinant CsrA-dimer (Re-CsrA) that contains a single CesT ...[more]