Ontology highlight
ABSTRACT:
SUBMITTER: Su Q
PROVIDER: S-EPMC5864754 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature communications 20180322 1
PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to be a nonselective cation channel that can be regulated by voltage, protons, and calcium. Despite its considerable importance, the molecular mechanisms underlying PKD2L1 regulations are largely unknown. Here, we determine the PKD2L1 atomic structure at 3.38 Å resolution by cryo-electron microscopy, whereby side chains of nearly all ...[more]