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Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation.


ABSTRACT: Neuregulin 1 (NRG1) is a growth factor produced by both peripheral nerves and skeletal muscle. In muscle, it regulates neuromuscular junction gene expression, acetylcholine receptor number, muscle homeostasis and satellite cell survival. NRG1 signalling is mediated by the tyrosine kinase receptors ErbB3 and ErbB4 and their co-receptors ErbB1 and ErbB2. The NRG1/ErbB system is well studied in nerve tissue after injury, but little is known about this system in skeletal muscle after denervation/reinnervation processes. Here, we performed a detailed time-course expression analysis of several NRG1 isoforms and ErbB receptors in the rat superficial digitorum flexor muscle after three types of median nerve injuries of different severities. We found that ErbB receptor expression was correlated with the innervated state of the muscle, with upregulation of ErbB2 clearly associated with the denervation state. Interestingly, the NRG1 isoforms were differently regulated depending on the nerve injury type, leading to the hypothesis that both the NRG1? and NRG1? isoforms play a key role in the muscle reaction to injury. Indeed, in vitro experiments with C2C12 atrophic myotubes revealed that both NRG1? and NRG1? treatment influences the best-known atrophic pathways, suggesting that NRG1 might play an anti-atrophic role.

SUBMITTER: Morano M 

PROVIDER: S-EPMC5864756 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation.

Morano Michela M   Ronchi Giulia G   Nicolò Valentina V   Fornasari Benedetta Elena BE   Crosio Alessandro A   Perroteau Isabelle I   Geuna Stefano S   Gambarotta Giovanna G   Raimondo Stefania S  

Scientific reports 20180322 1


Neuregulin 1 (NRG1) is a growth factor produced by both peripheral nerves and skeletal muscle. In muscle, it regulates neuromuscular junction gene expression, acetylcholine receptor number, muscle homeostasis and satellite cell survival. NRG1 signalling is mediated by the tyrosine kinase receptors ErbB3 and ErbB4 and their co-receptors ErbB1 and ErbB2. The NRG1/ErbB system is well studied in nerve tissue after injury, but little is known about this system in skeletal muscle after denervation/rei  ...[more]

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