Ontology highlight
ABSTRACT:
SUBMITTER: Morano M
PROVIDER: S-EPMC5864756 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Morano Michela M Ronchi Giulia G Nicolò Valentina V Fornasari Benedetta Elena BE Crosio Alessandro A Perroteau Isabelle I Geuna Stefano S Gambarotta Giovanna G Raimondo Stefania S
Scientific reports 20180322 1
Neuregulin 1 (NRG1) is a growth factor produced by both peripheral nerves and skeletal muscle. In muscle, it regulates neuromuscular junction gene expression, acetylcholine receptor number, muscle homeostasis and satellite cell survival. NRG1 signalling is mediated by the tyrosine kinase receptors ErbB3 and ErbB4 and their co-receptors ErbB1 and ErbB2. The NRG1/ErbB system is well studied in nerve tissue after injury, but little is known about this system in skeletal muscle after denervation/rei ...[more]