Ontology highlight
ABSTRACT:
SUBMITTER: Shin W
PROVIDER: S-EPMC5865148 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature communications 20180323 1
BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab i ...[more]