Ontology highlight
ABSTRACT:
SUBMITTER: Corbet C
PROVIDER: S-EPMC5865202 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Corbet Cyril C Bastien Estelle E Draoui Nihed N Doix Bastien B Mignion Lionel L Jordan Bénédicte F BF Marchand Arnaud A Vanherck Jean-Christophe JC Chaltin Patrick P Schakman Olivier O Becker Holger M HM Riant Olivier O Feron Olivier O
Nature communications 20180323 1
Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) represents an attractive therapeutic strategy but may stimulate glucose consumption by oxidative cancer cells. We report here that inhibition of mitochondrial pyruvate carrier (MPC) activity fulfils the tasks of blocking lactate use while preventing glucose oxidative metabolism. Using in vitro <sup>13</sup>C-glucose and in vivo ...[more]