Ontology highlight
ABSTRACT:
SUBMITTER: Marke R
PROVIDER: S-EPMC5865415 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Marke René R van Leeuwen Frank N FN Scheijen Blanca B
Haematologica 20180308 4
Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. <i>IKZF1</i> gene defects are associated with inferior treatment outcome in both childhood and adult B-cell precursor acute lymphoblastic leukemia and occur in more than 70% of <i>BCR-ABL1</i>-positive and <i>BCR-ABL1</i>-like cases of acute lymphoblastic leukemia. Over the past few years, much has been learned about t ...[more]