Dataset Information

Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma.

ABSTRACT:

Purpose

To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage.

Methods

In this cross-sectional study, 41 glaucoma patients and 12 age- and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation; optic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluation; and 3T MRI. Structure-structure and structure-function correlation were performed using bootstrap resampling method for clustered data.

Results

The ION mean diameter and cross-sectional area were different between glaucoma and control groups at 5mm and 10mm (all, p?0.011) from the globe, but not at 15mm (both, p?0.067). LGN height was significantly lower in glaucoma group (p = 0.005). OCT rim area and functional parameters (SAP and FDT) correlated significantly with all ION segments, showing stronger correlations at 10 and 15 mm. ION parameters at 10 and 15 mm presented mild-to-moderate correlation with OCT peripapillary nerve fiber layer thickness, and ION at 15mm had mild association with the neuroretinal rim area on stereophotographs. Although LGN height was significantly smaller in glaucoma group (p = 0.005), LGN parameters were not associated with any ocular structural or functional parameter.

Conclusion

Assessment of central and peripheral nervous systems using 3T MRI confirmed that glaucoma patients had smaller ION dimensions and LGN height compared to the control group. In general, ION dimensions presented mild to moderate correlations with functional and ocular structural parameters. Although ION had significant correlations at any distance from the eye, the ION distal locations correlated better with OCT results and functional parameters. However, LGN parameters were not associated with functional or ocular structural parameters.

SUBMITTER: Furlanetto RL

PROVIDER: S-EPMC5865716 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma.

Furlanetto Rafael Lacerda RL Teixeira Sergio Henrique SH Gracitelli Carolina Pelegrini Barbosa CPB Lottenberg Claudio Luiz CL Emori Fabiano F Michelan Michel M Amaro Edson E Paranhos Augusto A

PloS one 20180323 3

<h4>Purpose</h4>To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage.<h4>Methods</h4>In this cross-sectional study, 41 glaucoma patients and 12 age- and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation; optic disc stereophotograph, spectral- ...[more]

PMID: 29570721

Similar Datasets

Project description:PurposeTo investigate structural and functional correlations in glaucoma patients using optic nerve head hemoglobin (ONH Hb) measurements as determined by automated colorimetric analysis of conventional retinography.MethodsWe prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (standard automated perimetry, SAP), color fundus imaging (mydriatic retinography), and peripapillary retinal nerve fiber layer (pRNFL) assessment through spectral-domain optical coherence tomography (SD-OCT). Software Laguna ONhE was used to estimate the amount of ONH Hb and to determine the glaucoma discriminant function (GDF) index. Scatter plots were constructed, and regression analysis was used to investigate the correlations between GDF, average pRNFL thickness, and VF mean deviation (VFMD) index values. A secondary analysis was performed to compare each parameter between three different glaucoma groups divided according to VFMD values (mild, >-6 dB; moderate, -6 to -12 dB; and advanced, <-12 dB).ResultsOne hundred ninety-six eyes from 123 participants (69 with glaucoma and 54 controls) were enrolled. Overall, all parameters evaluated differed significantly between glaucomatous and control eyes (p ≤ 0.001). The comparison of each parameter according to groups of disease stages revealed significant differences between controls and each of the glaucomatous groups (p < 0.001). More pronounced changes in GDF values were observed in early disease stages. We found significant nonlinear correlations between GDF and VFMD values (R 2 = 0.295, p < 0.001) and between pRNFL thickness and VFMD (R 2 = 0.598, p < 0.001). A linear correlation was found between GDF and pRNFL thickness values (R 2 = 0.195, p < 0.001).ConclusionOur results showed significant associations between ONH Hb values and both structural and functional damage in glaucoma obtained by SD-OCT and SAP, respectively. The nonlinear correlation we found and the GDF behavior along different disease stages suggest that ONH Hb levels' reduction may precede visual function changes in early glaucoma stages.

Dataset Information

Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma.

Purpose

Methods

Results

Conclusion

Publications

Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma.

Similar Datasets

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