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Expression of long non?coding RNAs in human bone marrow mesenchymal stem cells co?cultured with human amnion?derived mesenchymal stem cells.

ABSTRACT: Long non?coding RNAs (lncRNAs) serve a critical role in various biological processes including cell growth, transcriptional regulation and differentiation. Previous studies have demonstrated that human amnion?derived mesenchymal stem cells (HAMSCs) possess the potential to promote proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). However, little is known about the roles of lncRNAs in these mechanisms. The present study investigated the expression of lncRNAs in HBMSCs co?cultured with HAMSCs to study their involvement in the mechanism of osteogenic differentiation. RNA sequencing was used to compare the lncRNA expression pro?les of HBMSCs co?cultured with or without HAMSCs during osteogenic differentiation. A total of 339 differentially expressed lncRNAs were identi?ed [log2 (fold change)>2.0 or

SUBMITTER: Wang J 

PROVIDER: S-EPMC5865784 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Expression of long non‑coding RNAs in human bone marrow mesenchymal stem cells co‑cultured with human amnion‑derived mesenchymal stem cells.

Wang Jingjing J   Miao Jing J   Meng Xin X   Chen Ning N   Wang Yuli Y  

Molecular medicine reports 20170912 5

Long non‑coding RNAs (lncRNAs) serve a critical role in various biological processes including cell growth, transcriptional regulation and differentiation. Previous studies have demonstrated that human amnion‑derived mesenchymal stem cells (HAMSCs) possess the potential to promote proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). However, little is known about the roles of lncRNAs in these mechanisms. The present study investigated the expression  ...[more]