Ontology highlight
ABSTRACT:
SUBMITTER: Hudson BH
PROVIDER: S-EPMC5866552 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hudson Benjamin H BH Hale Andrew T AT Irving Ryan P RP Li Shenglan S York John D JD
Proceedings of the National Academy of Sciences of the United States of America 20180305 12
Sulfur assimilation is an evolutionarily conserved pathway that plays an essential role in cellular and metabolic processes, including sulfation, amino acid biosynthesis, and organismal development. We report that loss of a key enzymatic component of the pathway, bisphosphate 3'-nucleotidase (Bpnt1), in mice, both whole animal and intestine-specific, leads to iron-deficiency anemia. Analysis of mutant enterocytes demonstrates that modulation of their substrate 3'-phosphoadenosine 5'-phosphate (P ...[more]