Dynamic patterns of cortical expansion during folding of the preterm human brain.

ABSTRACT: During the third trimester of human brain development, the cerebral cortex undergoes dramatic surface expansion and folding. Physical models suggest that relatively rapid growth of the cortical gray matter helps drive this folding, and structural data suggest that growth may vary in both space (by region on the cortical surface) and time. In this study, we propose a unique method to estimate local growth from sequential cortical reconstructions. Using anatomically constrained multimodal surface matching (aMSM), we obtain accurate, physically guided point correspondence between younger and older cortical reconstructions of the same individual. From each pair of surfaces, we calculate continuous, smooth maps of cortical expansion with unprecedented precision. By considering 30 preterm infant

SUBMITTER: Garcia KE 

PROVIDER: S-EPMC5866555 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature