Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC5866997 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Chen Jingxian J Akhtari Farida S FS Wagner Michael J MJ Suzuki Oscar O Wiltshire Tim T Motsinger-Reif Alison A AA Dumond Julie B JB
Clinical and translational science 20171203 2
Analysis of aging and pharmacogenetics (PGx) on antiretroviral pharmacokinetics (PKs) could inform precision dosing for older human HIV-infected patients. Seventy-four participants receiving either atazanavir/ritonavir (ATV/RTV) or efavirenz (EFV) with tenofovir/emtricitabine (TFV/FTC) provided PK and PGx information. Aging-PGx-PK association and interaction analyses were conducted using one-way analysis of variance (ANOVA), multiple linear regression, and Random Forest ensemble methods. Our ana ...[more]