Fecal microbiota transplantation in puppies with canine parvovirus infection.

ABSTRACT:

Background

Diarrhea associated with parvovirus infection is common in dogs. Supportive care is the mainstay of treatment, but recovery may be prolonged and mortality rate can be high. Modification of the intestinal bacterial microbiota has been promising in human and veterinary medicine as an adjunctive treatment of various enteric diseases.

Objectives

To investigate the safety and efficacy of fecal microbiota transplantation (FMT) on the clinical recovery of puppies with acute hemorrhagic diarrhea syndrome.

Animals

Sixty-six puppies with parvovirus infection were evaluated at 2 veterinary hospitals.

Methods

Randomized clinical trial. Puppies were randomly distributed into 2 groups: standard treatment (STD) and standard treatment?+?FMT (STD?+?FMT). The STD puppies (n?=?33) received only treatment with IV fluids and antimicrobials and the STD?+?FMT puppies (n?=?33) received FMT in addition to standard treatment. For FMT, 10 g of feces from a healthy dog diluted in 10 mL of saline were administered rectally 6-12 hours post-admission.

Results

Among survivors, treatment with FMT was associated with faster resolution of diarrhea (P?ConclusionsFecal microbiota transplantation in parvovirus-infected puppies was associated with faster resolution of diarrhea.

SUBMITTER: Pereira GQ 

PROVIDER: S-EPMC5867004 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature