Ontology highlight
ABSTRACT:
SUBMITTER: Khanna D
PROVIDER: S-EPMC5867414 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Khanna Dinesh D Denton Christopher P CP Lin Celia J F CJF van Laar Jacob M JM Frech Tracy M TM Anderson Marina E ME Baron Murray M Chung Lorinda L Fierlbeck Gerhard G Lakshminarayanan Santhanam S Allanore Yannick Y Pope Janet E JE Riemekasten Gabriela G Steen Virginia V Müller-Ladner Ulf U Spotswood Helen H Burke Laura L Siegel Jeffrey J Jahreis Angelika A Furst Daniel E DE
Annals of the rheumatic diseases 20171024 2
<h4>Objectives</h4>Assess the efficacy and safety of tocilizumab in patients with systemic sclerosis (SSc) in a phase II study.<h4>Methods</h4>Patients with SSc were treated for 48 weeks in an open-label extension phase of the faSScinate study with weekly 162 mg subcutaneous tocilizumab. Exploratory end points included modified Rodnan Skin Score (mRSS) and per cent predicted forced vital capacity (%pFVC) through week 96.<h4>Results</h4>Overall, 24/44 (55%) placebo-tocilizumab and 27/43 (63%) con ...[more]