Ontology highlight
ABSTRACT:
SUBMITTER: Zijlstra LE
PROVIDER: S-EPMC5867616 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Physiological genomics 20171208 2
Previous evidence suggest involvement of the complement receptor 1 (CR1) in development of Alzheimer's disease. We investigated the association of CR1 gene polymorphisms with cognitive function in older subjects. Single nucleotide polymorphisms (SNPs) within the CR1 region on chromosome 1 ( n = 73) were assessed in 5,244 participants in the PROspective Study of Pravastatin in the Elderly at Risk (51.9% female, mean age 75.3 yr). Linear regression, adjusted for age, sex, country, and use of prava ...[more]