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FOXG1 Expression Is Elevated in Glioma and Inhibits Glioma Cell Apoptosis.

ABSTRACT: FOXG1, a member of forkhead family transcriptional factor, is involved in telencephalon development. Recent studies showed FOXG1 was important for a variety of cellular events in cancer cells. In respect to glioma, FOXG1 has been shown to regulate cell proliferation and cell cycles. However, its impacts on other cellular events were not well studied. Here, we found FOXG1 had high expression in clinical glioma tissues, and its expression positively correlated with glioma malignancy. Moreover, we found FOXG1 played roles in glioma cell apoptosis. The expressions of caspase family members were significantly altered in response to change of FOXG1 expression, indicating a direct regulation of FOXG1 on caspase family members. These data strongly suggest FOXG1 is negative regulator of glioma cell apoptosis.

SUBMITTER: Chen J

PROVIDER: S-EPMC5868141 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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FOXG1 Expression Is Elevated in Glioma and Inhibits Glioma Cell Apoptosis.

Chen Jingying J Wu Xinmin X Xing Zhenkai Z Ma Chi C Xiong Wencheng W Zhu Xiaojuan X He Xiaoxiao X

Journal of Cancer 20180211 5

FOXG1, a member of forkhead family transcriptional factor, is involved in telencephalon development. Recent studies showed FOXG1 was important for a variety of cellular events in cancer cells. In respect to glioma, FOXG1 has been shown to regulate cell proliferation and cell cycles. However, its impacts on other cellular events were not well studied. Here, we found FOXG1 had high expression in clinical glioma tissues, and its expression positively correlated with glioma malignancy. Moreover, we ...[more]

PMID: 29581755

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